Recent Publications

Some of the recent journal publications are listed below. A complete list of publications is here. PDFs of seminar and conference presentations are here.

DoDE References

DRSM Publications

  • Klebanov, N., and C. Georgakis. 2016. “Dynamic Response Surface Models: A Data-Driven Approach for the Analysis of Time-Varying Process Outputs”, Ind. & Eng. Chem. Res., 55: 4022-34 http://doi.org/10.1021/acs.iecr.5b03572
  • Wang, Z. Y., and C. Georgakis. 2017. “New Dynamic Response Surface Methodology for Modeling Nonlinear Processes over Semi-infinite Time Horizons”, Ind. & Eng. Chem. Res., 56: 10770-82   http://doi.org/10.1021/acs.iecr.7b02381
  • Dong, Y. C., C. Georgakis, J. Mustakis, J. M. Hawkins, L. Han, K. Wang, J. P. McMullen, S. T. Grosser, and K. Stone. 2019. ‘Constrained Version of the Dynamic Response Surface Methodology for Modeling Pharmaceutical Reactions’, Ind. & Eng. Chem. Res., 58, (30): 13611-21 http://doi.org/10.1021/acs.iecr.9b00731  

  • Wang, Z. Y., C. Georgakis.  2019. “Identification of Hammerstein-Weiner models for nonlinear MPC from infrequent measurements in batch processes” J. of Proc. Cont., 82, 58-69 http://doi.org/10.1016/j.jprocont.2019.08.004

  • Wang, Z. Y. and C. Georgakis  (2019),  “A Dynamic Response Surface Model for Polymer Grade Transitions in Industrial Plants” Ind. & Eng. Chem. Res., 58, (26), pp. 11187-98, http://doi.org/10.1021/acs.iecr.8b04491

Stoichiometry publications

  • Dong, Y. C., C. Georgakis, J. Mustakis, J. M. Hawkins, L. Han, K. Wang, J. P. McMullen, S. T. Grosser, and K. Stone. 2019. ‘Stoichiometry identification of pharmaceutical reactions using the constrained dynamic response surface methodology’, AICHE J., 65 (11)   http://doi.org/10.1002/aic.16726
  • Santos-Marques, J., C. Georgakis, J. Mustakis, and J. M. Hawkins. 2019. “From dynamic response surface models to the identification of the reaction stoichiometry in a complex pharmaceutical case study”, AIChE J., 65 (4): 1173-85 http://doi.org/10.1002/aic.16515

Optimization publications

  • Dong, Y. C., C. Georgakis, J. Mustakis, L. Han, and J. P. McMullen. 2020. “Optimization of Pharmaceutical Reactions using the Dynamic Response Surface Methodology”, Comp. & Chem. Eng., 135: 106778 http://doi.org/10.1016/j.compchemeng.2020.106778
  • Wang, Z. Y., and C. Georgakis. 2017. “An in silico evaluation of data-driven optimization of biopharmaceutical processes”, AIChE J., 63: 2796-805 http://doi.org/10.1002/aic.15659

Operability Publications 

  • Tran, A. P., and C. Georgakis. 2018a. “On the estimation of high-dimensional surrogate models of steady-state of plant-wide processes characteristics”, Comp. & Chem. Eng., 116: 56-68 http://doi.org/10.1016/j.compchemeng.2018.02.014
  • Lima, F. V., and C. Georgakis. 2010. “Input-output operability of control systems: The steady-state case”, J. of Proc. Control, 20 (6): 769-76. => DOI: http://doi.org/10.1016/j.jprocont.2010.04.008
  • Lima, F. V., Z. Jia, M. G. Ierapetritou, and C. Georgakis. 2010. “Similarities and differences between the concepts of operability and flexibility: The steady-state case”, AIChE J., 56: 702-16 http://doi.org/10.1002/aic.12021
  • Georgakis, C., and L. Li. 2010. “On the Calculation of Operability Sets of Nonlinear High-Dimensional Processes”, Ind. Eng. Chem. Res., 49 (17): 8035-47 http://doi.org/10.1021/ie1009316
  • Lima, F. V., C. Georgakis, J. F. Smith, P. D. Schnelle, and D. R. Vinson. 2010. “Operability-Based Determination of Feasible Control Constraints for Several High-Dimensional Non-Square Industrial Processes”, AIChE J., 56 (5): 1249-61 http://doi.org/10.1002/aic.11897

Other Recent Publications 

  • Kiparissides, A., C. Georgakis, A. Mantalaris, and E. N. Pistikopoulos (2014), “Design of In Silico Experiments as a Tool for Nonlinear Sensitivity Analysis of Knowledge-Driven Models” Ind. & Eng. Chem. Res. 53 (18) pp. 7517-25, http://doi.org/10.1021/ie4032154
  • Cameron, I. T., S. Engell, C. Georgakis, N. Asprion, D. Bonvin, F. R. Gao, D. I. Gerogiorgis, I. E. Grossmann, S. Macchietto, H. A. Preisig, and B. R. Young. 2019. “Education in Process Systems Engineering: Why it matters more than ever and how it can be structured”, Comp. & Chem. Eng., 126: 102-12 http://doi.org/10.1016/j.compchemeng.2019.03.036
  • Daoutidis, P., J. H. Lee, I. Harjunkoski, S. Skogestad, M. Baldea, and C. Georgakis. 2018. “Integrating operations and control: A perspective and roadmap for future research”, Comp. & Chem. Eng., 115: 179-84 http://doi.org/10.1016/j.compchemeng.2018.04.011
  • Bonvin, D., C. Georgakis, C. C. Pantelides, M. Barolo, M. A. Grover, D. Rodrigues, R. Schneider, and D. Dochain. 2016.”‘Linking Models and Experiments”, Ind. & Eng. Chem. Res., 55 (25): 6891-903 http://doi.org/10.1021/acs.iecr.5b04801
  • Richards, J. R., M. Soroush, and C. Georgakis. 2014. “Preface for John P. Congalidis Memorial Special Issue “, Ind. & Eng. Chem. Res., 53 (18): 7273-74 http://doi.org/10.1021/ie5016552
  • Schneider, R., and C. Georgakis. 2013. “How To NOT Make the Extended Kalman Filter Fail”, Ind. & Eng. Chem. Res., 52 (9): 3354-62  http://doi.org/10.1021/ie300415d
  • Kavouras, A., C. Georgakis, C. T. Kelley, C. Siettos, and I. G. Kevrekidis. 2013. “Steady states for chemical process plants: A legacy code, time-stepping approach”, AIChE J., 59 (9): 3308-21 http://doi.org/10.1002/aic.14199
  • Hahn, J., C. Scali, M. Kano, C. Georgakis, L. Bergh, J. A. M. Perez, and K. Asano. 2013. “18th IFAC World Congress Milano, Italy, August 28 to September 2, 2011”, Journal of Process Control, 23 (2): 99-99 http://doi.org/10.1016/j.jprocont.2012.11.002
  • Troup, G. M., and C. Georgakis. 2013. “Process systems engineering tools in the pharmaceutical industry”, Comp. & Chem. Eng., 51: 157-71 http://doi.org/10.1016/j.compchemeng.2012.06.014
  • Georgakis, C. 2011. “A Data-Driven Modeling Approach Using the Design of Dynamic Experiments Methodology In Calculating the Design Space of Batch Pharmaceutical Processes.” In the 2011 AIChE Annual Meeting. Minneapolis, MN https://www.aiche.org/resources/proceedings/aiche-annual-meeting/2011
  • Bunin, Gene A., Fernando V. Lima, Christos Georgakis, and Christopher M. Hunt. 2010. “Model Predictive Control and dynamic Operability Studies in a Stirred Tank: Rapid Temperature Cycling for Crystallization”, Chem. Eng. Com., 197 (5): 733-52 http://doi.org/10.1080/00986440903288096
  •