Control Room--> Bioreactor Process Oil Refinery


Recent Modeling Breakthroughs

Our plans and research ideas are significantly shaped by two resent achievements in Professor Georgakis research group and a collaborative effort with Professor Lee.

  1. The first research breakthrough, described in a recently published paper, generalizes the classical Design of Experiments (DoE) Methodology for dynamic systems. The new methodology is called Design of Dynamic Experiments (DoDE). For more details see here: DoDE details (Link to News Page about DoDE)
  2. The second research breakthrough, described in a 2010 paper, has demonstrated that the development of some very simple meta-models, using the design of selective calculations of a detailed process models, will be very instrumental in performing challenging on-line calculations much more efficiently. This is because these simple meta-models have demonstrated that they are capable of representing complex process behaviors such as input multiplicity. More details (link to news page about meta-models)
  3. The third notable research result, described in a recently defended M.S. thesis , co-supervised with Prof. Lee, has utilized the design of the selective calculations, referred in the previous item, to postulate a nonlinear sensitivity (NLS) methodology for complex knowledge-driven models. Here a metabolic model for CHO cells was examined . This NLS methodology reveals which of the unknown parameters have the most significant impact on the model predictions and thus need to be estimated first. At the same this approach reveals the model parameters that have an insignificant effect on the model predictions. More details (link to news page about Nonlinear Sensitivity)

1"Design of Dynamic Experiments: A Data-Driven Methodology for the Optimization of Time-Varying Processes" Ind. Eng. Chem. Res., Articles ASAP (As Soon As Publishable) Publication Date (Web): May 3, 2013 (Article), DOI: 10.1021/ie3035114

2"On the Calculation of Operability Sets of Nonlinear High-Dimensional Processes" Ind. & Eng. Chemistry Research. 49 (17) pp. 8035-8047 (2010) DOI: 10.1021/ie1009316 (with L. Li)

3Hana's thesis

4Nolan, R.P. and K. Lee; "Dynamic model for CHO cell engineering" Journal of Biotechnology 158 (1-2) pp. 24-33 (2012), DOI: 10.1016/j.jbiotec.2012.01.009

SRI Director
Dr. Christos Georgakis
Professor, Department of Chemical and Biological Engineering, Gordon Senior Faculty Fellow of Systems Engineering
Tufts University
Affiliated Faculty at Tufts
Dr. Kyongbum Lee
Associate Professor and Chair, Department of Chemical and Biological Engineering
Tufts University
Dr. Nikhil Nair
Asistant Professor, Department of Chemical and Biological Engineering
Tufts University
Affiliated Faculty Outside Tufts
Dr. Bhavik Bakshi
Professor , Departmants of Chemical & Biomolecular Engineering, Ohio State University
Dr. Dominique Bonvin
Professor, Automatic Control Laboratory École Polytechnique Fédéral de Lausanne (EPFL) Switzerland
Dr. B. Erik Ydstie
Professor, Departmant of Chemical Engineering, Carnegie Mellon University, Professor of Electrical Engineering by Courtesy, CMU , and Professor II of Electrical Engineering at NUST, Trondheim, Norway
Contact SRI
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